منابع مشابه
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumour progression. We show that hypoxia-mediated downregulation of Drosha is dependent on ETS1/ELK1 tra...
متن کاملOvercoming tumour hypoxia
Cancer occurs as a result of genetic changes and the uncontrolled proliferation of abnormal cells that escape normal homeostatic control mechanisms. As tumour growth outstrips blood supply, cells become hypoxic and the decreased oxygen levels stimulate responses to maximise the chance of cell survival. These biological responses to hypoxia promote aggressive features in tumour cells. Also, hypo...
متن کاملTumour Selective Nuclear Targeting in a Tumour
PROGRESSION MODEL 2 3 Michael S. Nastasie, Helmut Thissen, David A. Jans and Kylie M. Wagstaff 4 Nuclear Signalling Laboratory, Dept. Biochemistry and Molecular Biology, Monash 5 University, Clayton, Victoria 3800, Australia 6 CSIRO Molecular and Health Technologies, Bayview Avenue, Clayton, Victoria 3168, 7 Australia 8 Running Title: Tumour selective nuclear targeting 9 10 *Correspondence shou...
متن کاملPET imaging of tumour hypoxia
Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and invasive techniques but the inter-relationships between these remains largely undefined. [18F]Fluoromisonidazole-3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18F]MISO) and Cu-diacetyl-bis(N4-m...
متن کاملHypoxia-inducible tumour-specific promoters as a dual-targeting transcriptional regulation system for cancer gene therapy
Transcriptional targeting is the best approach for specific gene therapy. Hypoxia is a common feature of the tumour microenvironment. Therefore, targeting gene expression in hypoxic cells by placing transgene under the control of a hypoxia-responsive promoter can be a good strategy for cancer-specific gene therapy. The hypoxia-inducible gene expression system has been investigated more in suici...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2003
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3301944